Tracey John's from the Multiplayer Blog has talked with the producer of Resident Evil 5 and received a "must do" list for the game. List in the quote, for the reasons why you must do these things, click the source (there is a lot).

Neck Twist /Silent Knife Defense Trick

Finish with a BLOW!

Aim and shoot driver on the armored truck

Kill Licker with one attack

100% Target Rate

Use the Machine Gun VZ61 to avoid filling up your item slots with ammo

Use eggs (rotten?)! But don’t eat them

Collect BSAA emblems

Provoke your enemy

Finish Gatling Majini by yourself with a blow

More fun on co-op with exclamations!

Courageous Josh

How to handle fearful enemy Leaper

Walk softly and avoid battle against Licker

Speed reloading using Item Slot

Use Sensor Bomb

Kill all of the first Majini horde

Item hidden in tomato

Collect Figures

Try the first “Resident Evil” VS mode

PacoDG via multiplayerblog.mtv.com »