4. Dante and Trish - Devil May Cry Series (PS2)
If the best girl a man can find is one that reminds him of his mother, then Dante has certainly hit the jackpot. Created by the demon lord Mundus during the first game to resemble the devil hunter's mother Eva, Trish wound up developing feelings for Dante, helping him to defeat Mundus and ending up as his partner. While the fact that her feelings stem from being made in his mother's image is kind of creepy if you stop and think about it, there's no denying Trish and Dante were made for each other - well, at least she was.

3. Jackie Estacado and Jenny - The Darkness (Xbox 360, PS3)
This pair grew up together as orphans, and mob thug Jackie spent most of his life shielding the innocent and sweet Jenny from the horrors of the seedy underworld he moved about in. If I had to pick the single most emotionally charged moment in gaming from last year, it would be the moment Jackie Estacado and his girlfriend Jenny cease to be a couple, so to speak. I won't ruin for anyone who still hasn't played the game, but I got so *bleep*king angry I stayed up the whole night to finish the game.

2.Tidus and Yuna - Final Fantasy X (PS2)
A summoner of Yevon destined to die, Yuna finds the man of her dreams in mismatched pants leg blitzball star Tidus. Unfortunately, over the course of Final Fantasy X we learn the Tidus is the man of the fayth's dreams as well, with the end of the game finding him fading away as he desperately tries to hold onto her.